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New study from Prof. Haojian Zhang's laboratory reveals an important role of YBX1 in acute myeloid leukemia
On March 24, 2021, the international renowned journal BLOOD published an article entitled "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner", reported the molecular mechanism of YBX1 in selectively regulating the survival of myeloid leukemia cells. This work came from Dr. Haojian Zhang’s laboratory. Dr. Zhang is a profess...
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Cell research published the latest results of Dr. Bo Zhong's research team
On May 26, 2020, Prof. Bo Zhong’s group published an article entitled "USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity" on Cell Research (https://www.nature.com/articles/s41422-020-0341-6). In this study, they found a critical role of USP29 in the innate immune responses against DNA viruses and autoimmune diseases by regulating cyclic GMP-AMP sy...
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Lin, H., Feng, L., Cui, K.S., Zeng, L.W., Gao, D., Zhang, L.X., Xu, W.H., Sun, Y.H., Shu, H.B.*, and Li, S.* (2021). The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis. Cell Mol Immunol.（舒红兵、李姝）AbstractThe IL-6-STAT3 axis is critically involved in inflammation-associated carcinogenesis (IAC). How this axi...
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Yin, R., Chang, J., Li, Y., Gao, Z., Qiu, Q., Wang, Q., Han, G., Chai, J., Feng, M., Wang, P., ..., Zhang, H.* (2021). Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell.（张好建）AbstractN6-methyladenosine (m6A) on mRNA plays critical roles in various cellular processes. However, the landscape and dy...
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Wang, P., Yang, W., Guo, H., Dong, H.P., Guo, Y.Y., Gan, H., Wang, Z., Cheng, Y., Deng, Y., Xie, S., Yang, X., Lin, D.*, Zhong, B.* (2021). IL-36gamma and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. Adv Sci (Weinh), e2101501.（钟波）AbstractThe balance between antioxidants and reactive oxygen species (ROS) critically reg...
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Huang, J., Liang, Z., Guan, C., Hua, S., and Jiang, K.* (2021). WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin. J Cell Biol 220.（姜恺）AbstractWDR62 is a microcephaly-related, microtubule (MT)-associated protein (MAP) that localizes to the spindle pole and regulates spindle organization, but the underlying mechanisms remain elusive. Here, we show tha...
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Liu, R., Zeng, L.W., Gong, R., Yuan, F., Shu, H.B., and Li, S.* (2021). mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nat Commun 12, 4227.（李姝）AbstractGlycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and pl...
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